<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><meta http-equiv=Content-Type content="text/html; charset=iso-2022-jp"><meta name=Generator content="Microsoft Word 15 (filtered medium)"><!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"MS Gothic";
panose-1:2 11 6 9 7 2 5 8 2 4;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:"\@MS Gothic";
panose-1:2 11 6 9 7 2 5 8 2 4;}
@font-face
{font-family:"MS PGothic";
panose-1:2 11 6 0 7 2 5 8 2 4;}
@font-face
{font-family:"\@MS PGothic";}
@font-face
{font-family:"Lucida Sans";
panose-1:2 11 6 2 3 5 4 2 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:JA;}
h2
{mso-style-priority:9;
mso-style-link:"Heading 2 Char";
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:18.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:JA;
font-weight:bold;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
span.Heading2Char
{mso-style-name:"Heading 2 Char";
mso-style-priority:9;
mso-style-link:"Heading 2";
font-family:"Calibri",sans-serif;
font-weight:bold;}
span.date-display-single
{mso-style-name:date-display-single;}
span.date-display-range
{mso-style-name:date-display-range;}
span.date-display-start
{mso-style-name:date-display-start;}
span.date-display-end
{mso-style-name:date-display-end;}
span.fn
{mso-style-name:fn;}
span.map-icon
{mso-style-name:map-icon;}
span.locality
{mso-style-name:locality;}
span.region
{mso-style-name:region;}
span.postal-code
{mso-style-name:postal-code;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1027" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]--></head><body lang=EN-US link="#0563C1" vlink="#954F72" style='word-wrap:break-word'><div class=WordSection1><p class=MsoNormal><b><i><span style='font-size:14.0pt'>In-Person seminars will be held at Dunham Lab, 10 Hillhouse Ave., Room 220, with an option of remote participation via zoom.<o:p></o:p></span></i></b></p><p class=MsoNormal><b><i><span style='font-size:14.0pt'>3:30pm - Pre-talk meet & greet, DL 228 <o:p></o:p></span></i></b></p><p class=MsoNormal><i><o:p> </o:p></i></p><p class=MsoNormal style='background:white'><span style='color:black'><a href="https://statistics.yale.edu/" title="Department of Statistics and Data Science
"><span style='font-size:22.0pt;font-family:"Lucida Sans",sans-serif;color:#286DC0;text-decoration:none'><img border=0 width=150 height=49 style='width:1.5625in;height:.5104in' id=logo src="cid:image001.jpg@01D8D960.CBAAB600" alt="Department of Statistics and Data Science
"></span></a> <a href="https://statistics.yale.edu/" title=Home><b><span style='font-size:22.0pt;font-family:"Lucida Sans",sans-serif;color:#286DC0'>Department of Statistics and Data Science </span></b></a></span><b><i><u><span style='font-size:22.0pt;font-family:"Lucida Sans",sans-serif;color:#286DC0'> <o:p></o:p></span></u></i></b></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Arial",sans-serif'>Zongming Ma, University of Pennsylvania<o:p></o:p></span></p><p class=MsoNormal><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
<v:stroke joinstyle="miter" />
<v:formulas>
<v:f eqn="if lineDrawn pixelLineWidth 0" />
<v:f eqn="sum @0 1 0" />
<v:f eqn="sum 0 0 @1" />
<v:f eqn="prod @2 1 2" />
<v:f eqn="prod @3 21600 pixelWidth" />
<v:f eqn="prod @3 21600 pixelHeight" />
<v:f eqn="sum @0 0 1" />
<v:f eqn="prod @6 1 2" />
<v:f eqn="prod @7 21600 pixelWidth" />
<v:f eqn="sum @8 21600 0" />
<v:f eqn="prod @7 21600 pixelHeight" />
<v:f eqn="sum @10 21600 0" />
</v:formulas>
<v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect" />
<o:lock v:ext="edit" aspectratio="t" />
</v:shapetype><v:shape id="Picture_x0020_3" o:spid="_x0000_s1026" type="#_x0000_t75" style='position:absolute;margin-left:0;margin-top:.3pt;width:117.1pt;height:140.5pt;z-index:251658240;visibility:visible;mso-wrap-style:square;mso-width-percent:0;mso-height-percent:0;mso-wrap-distance-left:9pt;mso-wrap-distance-top:0;mso-wrap-distance-right:9pt;mso-wrap-distance-bottom:0;mso-position-horizontal:absolute;mso-position-horizontal-relative:text;mso-position-vertical:absolute;mso-position-vertical-relative:text;mso-width-percent:0;mso-height-percent:0;mso-width-relative:page;mso-height-relative:page'>
<v:imagedata src="cid:image002.jpg@01D8D960.CBAAB600" o:title="" />
<w:wrap type="square"/>
</v:shape><![endif]--><![if !vml]><img width=156 height=187 style='width:1.625in;height:1.9479in' src="cid:image004.jpg@01D8DC98.6825FF50" align=left hspace=12 v:shapes="Picture_x0020_3"><![endif]><span style='font-family:"Arial",sans-serif'><o:p></o:p></span></p><p class=MsoNormal><span class=fn><b><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>Date: </span></b></span><span class=fn><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>Monday</span></span><span class=date-display-single><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>, October 10, 2022</span></span><span class=date-display-single><span style='font-size:12.0pt'><o:p></o:p></span></span></p><p class=MsoNormal><span class=fn><b><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>Talk Time:</span></b></span><span class=date-display-single><span style='font-size:12.0pt;font-family:"Arial",sans-serif'> </span></span><span class=date-display-start><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>4:00PM</span></span><span class=date-display-range><span style='font-size:12.0pt;font-family:"Arial",sans-serif'> to </span></span><span class=date-display-end><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>5:00PM</span></span><o:p></o:p></p><p class=MsoNormal><span class=fn><b><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>Meeting Location:</span></b></span><span class=fn><span style='font-size:12.0pt;font-family:"Arial",sans-serif'> Dunham Lab. Room 220</span></span><span style='font-size:12.0pt;font-family:"Arial",sans-serif'> <span class=map-icon><span style='letter-spacing:.6pt'><a href="http://maps.google.com/?q=10+Hillhouse+Avenue%2C+Rm.+220%2C+New+Haven%2C+CT%2C+06511%2C+us"><span style='color:windowtext'>see map</span></a> </span></span><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>10 Hillhouse Avenue<o:p></o:p></span></p><p class=MsoNormal><span class=locality><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>New Haven</span></span><span style='font-size:12.0pt;font-family:"Arial",sans-serif'>, <span class=region>CT</span> <span class=postal-code>06511</span><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Arial",sans-serif'><a href="http://www-stat.wharton.upenn.edu/~zongming/"><span style='color:#003C76'>Website</span></a><o:p></o:p></span></p><p class=MsoNormal style='background:white'><span class=fn><b><i><span style='font-size:12.0pt;font-family:"Arial",sans-serif;color:black'>OR</span><o:p></o:p></i></b></span></p><p class=MsoNormal style='background:white'><span class=fn><b><span style='font-size:12.0pt;font-family:"Arial",sans-serif;color:black'>Zoom meeting link:</span></b></span><span style='font-size:12.0pt;font-family:"Arial",sans-serif;color:black'> <a href="https://yale.zoom.us/j/92411077917?pwd=aXhnTnFGRXFoaTVDczNjeFFKeWpTQT09">https://yale.zoom.us/j/92411077917?pwd=aXhnTnFGRXFoaTVDczNjeFFKeWpTQT09</a> / Password: 24</span><o:p></o:p></p><p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Arial",sans-serif'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-size:15.0pt;font-family:"Arial",sans-serif'>Title: Matching and integration of datasets with low-rank signals and applications in single-cell data analysis<o:p></o:p></span></b></p><p class=MsoNormal><b><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-family:"Arial",sans-serif'>Information and Abstract: <o:p></o:p></span></b></p><p style='margin:0in;text-align:justify;text-justify:inter-ideograph;line-height:150%;box-sizing: inherit'><span style='font-family:"Arial",sans-serif'>We study one-way matching of a pair of datasets with low-rank signals. Under a stylized model, we first derive information-theoretic limits of matching under a mismatch proportion loss. We then show that linear assignment with projected data achieves fast rates of convergence and sometimes even rate optimality for this task. Built upon this theoretical understanding, we propose a new matching algorithm, Matching with pARtIal Overlap (MARIO), that takes into account both shared and distinct features in related datasets. MARIO accurately matches and integrates data from different single-cell methods. As an exemplary application, it robustly matched tissue macrophages identified from COVID-19 lung autopsies via CODEX imaging to macrophages recovered from COVID-19 bronchoalveolar lavage fluid via CITE-seq to provide evidence for orchestrated immune responses within the lung microenvironment of COVID patients. <o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Arial",sans-serif'>Join from PC, Mac, Linux, iOS or Android: <a href="https://yale.zoom.us/j/92411077917?pwd=aXhnTnFGRXFoaTVDczNjeFFKeWpTQT09"><span style='color:#286DC0'>https://yale.zoom.us/j/92411077917?pwd=aXhnTnFGRXFoaTVDczNjeFFKeWpTQT09</span></a><br>Password: 24<br>Or Telephone</span><span lang=JA style='font-family:"MS Gothic"'>：</span><span style='font-family:"Arial",sans-serif'>203-432-9666 (2-ZOOM if on-campus) or 646 568 7788<br>Meeting ID: 924 1107 7917<o:p></o:p></span></p><h2 style='mso-margin-top-alt:0in;margin-right:0in;margin-bottom:6.0pt;margin-left:0in;box-sizing: inherit;font-feature-settings: "kern", "liga", "dlig"'><span style='font-family:"Arial",sans-serif;font-weight:normal'><o:p> </o:p></span></h2><h2 style='mso-margin-top-alt:0in;margin-right:0in;margin-bottom:6.0pt;margin-left:0in'><span style='font-size:12.0pt;font-family:"Arial",sans-serif;color:black'>For more details and upcoming events visit our website at <a href="http://statistics.yale.edu/"><span style='color:black'>http://statistics.yale.edu/</span></a>. </span><span style='font-family:"Arial",sans-serif;font-weight:normal'><o:p></o:p></span></h2><h2 style='margin:0in'><span style='font-family:"Arial",sans-serif;font-weight:normal'>Department of Statistics and Data Science<o:p></o:p></span></h2><p style='margin:0in;box-sizing: inherit'><span style='font-size:9.0pt;font-family:"Arial",sans-serif;color:black'>Yale University<br>24 Hillhouse Avenue<br>New Haven, CT 06511<o:p></o:p></span></p><p style='margin:0in;box-sizing: inherit'><span style='font-size:9.0pt;font-family:"Arial",sans-serif;color:black'>t 203.432.0666<br>f 203.432.0633<o:p></o:p></span></p><p class=MsoNormal style='line-height:18.0pt;background:white'><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Arial",sans-serif'><o:p> </o:p></span></p></div></body></html>