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<span style="font-family: Arial, sans-serif; font-size: 22pt; color: rgb(40, 109, 192);"><u><a href="https://statistics.yale.edu/" id="OWA9f664dc3-6347-8944-3cf0-cc654066c40d" class="OWAAutoLink" title="Department of Statistics and Data Science" data-auth="NotApplicable" style="color: rgb(40, 109, 192); margin-top: 0px; margin-bottom: 0px;"><img alt="Department of Statistics and Data Science" id="x_logo" width="150" height="48" size="3175" contenttype="image/jpeg" style="width: 1.5625in; height: 0.5104in; margin-top: 0px; margin-bottom: 0px;" data-outlook-trace="F:1|T:1" src="cid:image001.jpg@01DB70A5.38ED4470"></a></u></span><span style="font-family: Arial, sans-serif; color: black;">
</span><span style="font-family: Arial, sans-serif; font-size: 22pt; color: rgb(40, 109, 192);"><b><u><a href="https://statistics.yale.edu/" id="OWA778aef30-a1ef-e08b-4d5e-84ceb8583fb4" class="OWAAutoLink" title="Home" data-auth="NotApplicable" style="color: rgb(40, 109, 192); margin-top: 0px; margin-bottom: 0px;">Department
of Statistics and Data Science</a></u></b></span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;"> </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 14pt;"><b>Xiang Zhou, University of Michigan</b></span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><img width="130" height="156" size="40329" contenttype="image/png" style="width: 1.3645in; height: 1.6354in; margin-top: 0px; margin-bottom: 0px; float: left;" data-outlook-trace="F:1|T:1" src="cid:image003.png@01DB70AD.348CD6E0"><span style="font-family: Arial, sans-serif; font-size: 12pt;">Date:
Monday, February 03, 2025</span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;">Time: 12:00PM to 1:00PM</span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;">Location: Kline Tower, 13th Floor, Rm. 1327
</span><span style="font-family: Arial, sans-serif; font-size: 12pt; color: rgb(70, 120, 134);"><u><a href="http://maps.google.com/?q=219+Prospect+Street%2C+New+Haven%2C+CT%2C+06511%2C+us" id="OWA611903bf-4008-e09e-ed58-bce89e0c2778" class="OWAAutoLink" data-auth="NotApplicable" style="color: rgb(70, 120, 134); margin-top: 0px; margin-bottom: 0px;">See
map</a></u></span><span style="font-family: Arial, sans-serif; font-size: 12pt;"> </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;">219 Prospect Street</span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;">New Haven, CT 06511</span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;"> </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;">Webcast:
</span><span style="font-family: Arial, sans-serif; font-size: 12pt; color: rgb(70, 120, 134);"><u><a href="https://yale.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=7b56c54c-e254-4cd4-bd46-b25a013eb54c" id="OWAc22533d9-b85b-f9fb-5d2b-abecc220296a" class="OWAAutoLink" data-auth="NotApplicable" style="color: rgb(70, 120, 134); margin-top: 0px; margin-bottom: 0px;">https://yale.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=7b56c54c-e254-4cd4-bd46-b25a013eb54c</a></u></span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;"> </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;"><b> </b></span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif;"><b>Statistical and Computational Methods for Genetic and Genomic Studies</b></span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;"> </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;">Information and Abstract: </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;">I will talk about a few statistical and computational methods we have developed over the past few years to give you a flavor
of the type of work we do in our group. My talk will focus on two distinct application areas: genome-wide association studies and spatial multi-omics studies. Specifically, I will talk about Dirichlet process regression, or DPR, a non-parametric Bayesian regression
method that flexibly and adaptively models the effect size distribution to enable accurate and robust polygenic risk prediction across a broad spectrum of genetic architectures. I will talk about SPARK, a method that allows for rigorous statistical analysis
of spatial expression patterns in spatial transcriptomics, along with its non-parametric extension, SPARK-X, for scalable detection of spatially expressed genes in large spatial transcriptomic studies. If time allows, I will also talk about a scalable multi-ancestry
variational fine-mapping method, MESuSiE, that accounts for the diverse linkage disequilibrium pattern observed in different ancestries while explicitly modeling both shared and ancestry-specific causal SNPs; as well as a spatially informed cell type deconvolution
method, CARD, that leverages cell type specific expression information from single cell RNA sequencing for the deconvolution of spatial transcriptomics. </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;"> </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt;"><b>Lunch at 11:30am in room 1307<br>
Talk at 12:00-1:00pm in room 1327A</b></span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Calibri, sans-serif; font-size: 12pt;"><i> </i></span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 12pt; color: black;">For more details and upcoming events visit our website at
</span><span style="font-family: Arial, sans-serif; font-size: 12pt; color: rgb(70, 120, 134);"><u><a href="https://statistics.yale.edu/calendar" id="OWAea196b6f-ad10-3adc-26a8-7ca553016308" class="OWAAutoLink" data-auth="NotApplicable" style="color: rgb(70, 120, 134); margin-top: 0px; margin-bottom: 0px;">https://statistics.yale.edu/calendar</a></u></span><span style="font-family: Arial, sans-serif; font-size: 12pt;">.</span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif;"> </span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 18pt;">Department of Statistics and Data Science</span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 9pt; color: black;">Yale University<br>
Kline Tower</span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="font-family: Arial, sans-serif; font-size: 9pt; color: black;">219 Prospect Street<br>
New Haven, CT 06511</span></p>
<p style="margin: 0in; font-family: Aptos, sans-serif; font-size: 11pt;"><span style="color: rgb(70, 120, 134);"><u><a href="https://statistics.yale.edu/" id="OWAaa096f1c-b1ca-12c0-9eec-54493c42ace7" class="OWAAutoLink" data-auth="NotApplicable" style="color: rgb(70, 120, 134); margin-top: 0px; margin-bottom: 0px;">https://statistics.yale.edu/</a></u></span></p>
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