<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:DengXian;
panose-1:2 1 6 0 3 1 1 1 1 1;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:"\@DengXian";
panose-1:2 1 6 0 3 1 1 1 1 1;}
@font-face
{font-family:"Microsoft YaHei";
panose-1:2 11 5 3 2 2 4 2 2 4;}
@font-face
{font-family:"\@Microsoft YaHei";}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
.MsoChpDefault
{mso-style-type:export-only;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.25in 1.0in 1.25in;}
div.WordSection1
{page:WordSection1;}
--></style>
</head>
<body lang="EN-US" link="blue" vlink="#954F72" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal">For those who are interested but cannot make it on site, there is also a Zoom link:</p>
<p class="MsoNormal"><a href="https://yale.zoom.us/j/5749562169">https://yale.zoom.us/j/5749562169</a></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Best,<o:p></o:p></p>
<p class="MsoNormal">Kai (Jack)<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<div style="mso-element:para-border-div;border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal" style="border:none;padding:0in"><b>From: </b><a href="mailto:jack.zhang@yale.edu">Zhang, Jack</a><br>
<b>Sent: </b>Wednesday, June 14, 2023 11:17 PM<br>
<b>To: </b><a href="mailto:YSM_Structural_Biology_Seminar_Series@mailman.yale.edu">YSM_Structural_Biology_Seminar_Series@mailman.yale.edu</a>;
<a href="mailto:cryoem-journalclub@mailman.yale.edu">CryoEM List</a>; <a href="mailto:cryoem@yale.edu">
cryoem</a>; <a href="mailto:mbb.seminars@yale.edu">Yale MBB Seminar Program</a><br>
<b>Cc: </b><a href="mailto:mbbfacultyall@mailman.yale.edu">mbbfacultyall@mailman.yale.edu</a><br>
<b>Subject: </b>Re: [Cilia] Ji Sun's visit</p>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Sorry, colleagues, two things: (1) It seemed my post to YSM structural bio list failed (?), and I had to resend this email. (2) Our honorable Prof. Rosenbaum has told me to stop asking silly questions
such as 'whether people are interested in a certain topic or not'. So sorry about my brainlessness, and I really apologize for my 'wrongdoing' to even inquire about people's interest.
<o:p></o:p></span></p>
</div>
<div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
</div>
<div id="Signature">
<div>
<div>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">Best,<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">Kai (Jack)<o:p></o:p></span></p>
</div>
</div>
</div>
</div>
<div>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
</div>
<p class="MsoNormal"><img border="0" width="463" height="2" style="width:4.8194in;height:.0208in" id="Horizontal_x0020_Line_x0020_1" src="cid:image002.png@01D9A03C.F9E1FF80"><o:p></o:p></p>
<div id="divRplyFwdMsg">
<p class="MsoNormal"><b><span style="color:black">From:</span></b><span style="color:black"> Zhang, Jack<br>
<b>Sent:</b> Wednesday, June 14, 2023 9:13 PM<br>
<b>To:</b> Rosenbaum, Joel <joel.rosenbaum@yale.edu><br>
<b>Cc:</b> Breslow, David <david.breslow@yale.edu><br>
<b>Subject:</b> Re: [Cilia] Ji Sun's visit</span> <o:p></o:p></p>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
</div>
<div>
<div>
<div>
<p class="MsoNormal">Dear Prof. Rosenbaum,<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal" style="margin-bottom:12.0pt">I apologize for asking people in the cilia group if they are interested (I did not realize how stupid the question was until you reminded me). I am so sorry and will avoid asking such questions again in future.
Also, I feel I should have let you know well before this notice. Ji clearly expressed his admirations for the many groundbreaking discoveries made by Yale senior colleagues, especially you, your group and your many trainees. Without your discovery, the field
itself wouldn't have existed.<o:p></o:p></p>
<div>
<p class="MsoNormal">Best,<br>
Kai (Jack)<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
<div>
<p class="MsoNormal">2023<span lang="ZH-CN" style="font-family:"Microsoft YaHei",sans-serif">年</span>6<span lang="ZH-CN" style="font-family:"Microsoft YaHei",sans-serif">月</span>14<span lang="ZH-CN" style="font-family:"Microsoft YaHei",sans-serif">日</span>
20:17<span lang="ZH-CN" style="font-family:"Microsoft YaHei",sans-serif">，</span>Joel Rosenbaum <joel.rosenbaum@yale.edu><span lang="ZH-CN" style="font-family:"Microsoft YaHei",sans-serif">写道：</span><o:p></o:p></p>
<blockquote style="border:none;border-left:solid #CCCCCC 1.0pt;padding:0in 0in 0in 6.0pt;margin-left:4.8pt;margin-right:0in">
<div>
<div>
<p class="MsoNormal">Interested? Of course we're interested! Why wouldn't we be? We have<br>
a large and active cilia seminar group, and IFT was discovered here.<br>
Moreover, at least one of us has mentored the leading structural<br>
biologist working and publishing on IFT, Gaia Pigino.<br>
<br>
David, please inform the Cilia Group of this seminar.<br>
<br>
Joel Rosenbaum<br>
Professor MCDB, Yale<br>
<br>
On Wed, Jun 14, 2023 at 7:47 PM Zhang, Jack <jack.zhang@yale.edu> wrote:<br>
><br>
> Dear colleagues,<br>
><br>
><br>
><br>
> Dr. Ji Sun from St. Jude is visiting Yale this Friday. He will give an informal seminar talk titled “Structural Basis of LRRK2 Activation- a novel molecular paradigm of kinase spatial regulation”, in Bass 405, at 11 AM.<br>
><br>
><br>
><br>
> Dr. Ji Sun stood out as one of the most extraordinary colleagues during our time at IBP. From the moment we embarked on our scientific journeys, I was certain that his remarkable intellect and passion would propel him to become a highly accomplished scientist
- a prediction that has been beautifully realized. Ji earned his doctorate at the University of Washington (with Ning Zhen), and subsequently furthered his postdoctoral research work in Rod MacKinnon’s lab at Rockefeller.<br>
><br>
><br>
><br>
> Dr. Sun's reputation in the broad field of structural biology is truly exceptional. His remarkable discoveries have made groundbreaking contributions to our scientific understanding, including a series of high-resolution, high-impact protein structures. Notably,
he solved the first atomic model of LRRK2 (published in Cell, 2021), as well as highly impressive atomic models of IFT-A/B train (published in Cell Research, 2023), and several other important membrane protein complexes.<br>
><br>
><br>
><br>
> Exemplifying both passion and proficiency in his scientific pursuits, Dr. Sun's track record is extraordinary. Upon establishing his lab at St. Jude, he made an impressive debut by publishing his laboratory's first paper in the prestigious journal NSMB as
the ‘sole author’. This remarkable achievement surprised and inspired all his peers, highlighting his unique blend of dedication, intellect, and innovative thinking.<br>
><br>
><br>
><br>
> In his talk this Friday, he will present some very impressive findings on the molecular mechanism of LRRK2, in addition to his recent work in Cell. During the past couple of decades, laboratories across the globe, including some of our former colleagues at
the Institute of Biophysics (since 10+ ago without any luck/success, as far as I know), have wrestled with the complex challenge of decoding the structure of LRRK2, a crucial puzzle piece in the battle against Parkinson's disease. Despite persistent efforts,
substantial progress remained elusive until Dr. Sun's groundbreaking discovery. His seminar at Yale will delve into the journey and the potential real-world implications of his work on LRRK2, offering a unique perspective on the intersection of cutting-edge
structural biology and potential therapeutic applications.<br>
><br>
><br>
><br>
> In addition, Dr. Sun has recently started working on ciliary structures, and has solved several incredible structures in this system including IFT-A/B train<b><s>, if anyone in this field is also interested.</s></b><br>
><br>
><br>
><br>
> Best,<br>
><br>
> Kai (Jack)<br>
><br>
><br>
><br>
> _______________________________________________<br>
> Cilia mailing list<br>
> Cilia@mailman.yale.edu<br>
> <a href="https://mailman.yale.edu/mailman/listinfo/cilia">https://mailman.yale.edu/mailman/listinfo/cilia</a><o:p></o:p></p>
</div>
</div>
</blockquote>
</div>
</div>
</div>
</div>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
</body>
</html>