[Sds-seminars] S&DS Seminar via Zoom, Renato Polimanti, 10/04 @ 4pm-5pm, " Big Data Analytics Applied to the Molecular Basis of Human Traits and Diseases"

[elizavette.torres at yale.edu]

   <https://statistics.yale.edu/> Department of Statistics and Data Science


You are invited to a scheduled Zoom Seminar


RENATO POLIMANTI, Yale University School of Medicine


Monday, October 04, 2021

4:00PM to 5:00PM

Zoom:
https://yale.zoom.us/j/99169700816?pwd=SWEvWHI5d3dPNVdHMkZMZURMWWJPUT09 

Password: 24

 

 

 

 

Title: Big Data Analytics Applied to the Molecular Basis of Human Traits and
Diseases

 

Information and Abstract: 

Most human traits and diseases are characterized by a complex molecular
architecture where a wide range of biological pathways contribute to their
predisposition. Hypothesis-generating studies based on genomic screening (e.
g., genome-wide association studies, epigenome-wide association studies,
whole-genome sequencing, RNA sequencing, and bisulfite genomic sequencing)
are a powerful approach to dissect the polygenicity of the human phenome.
However, to be informative, these approaches require large cohorts
achievable with the integration of international consortia and large
biobanks to pool together samples and reach an adequate statistical power.
Beyond the identification of specific genes associated with traits and
diseases, large-scale genomic datasets can be used to investigate the
biology of the human phenotypic spectrum, modeling causal networks and
molecular mechanisms shared among physiological and pathological conditions.
Due to the growing number of large-scale genomic datasets available, there
is a rapid increase of methods to conduct computational investigations. The
goal of this seminar is to provide an overview of how we can use Big Data
Analytics to dissect the molecular basis of human traits and diseases. I
will present few examples of the studies conducted by my group, also
including collaborations with the Psychiatric Genomics Consortium, the
Million Veteran Program, and the COVID-19 Host Genetics Initiative, I will
describe current challenges and limitations and discuss the need to develop
new analytic approaches to improve our ability to translate molecular
findings into clinical practice.

 

Zoom is Yale’s audio and visual conferencing platform.

Topic: Yale S&DS Department Seminar

Time: 4:00pm - 5:00pm

Join from PC, Mac, Linux, iOS or Android:
<https://yale.zoom.us/j/99169700816?pwd=SWEvWHI5d3dPNVdHMkZMZURMWWJPUT09>
https://yale.zoom.us/j/99169700816?pwd=SWEvWHI5d3dPNVdHMkZMZURMWWJPUT09

    Password: 24

    Or Telephone：203-432-9666 (2-ZOOM if on-campus) or 646 568 7788

    Meeting ID: 991 6970 0816

    International numbers available:  <https://yale.zoom.us/u/acBOaD1ic6>
https://yale.zoom.us/u/acBOaD1ic6

For H.323 and SIP information for video conferencing units please click
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