[Sds-seminars] S&DS Seminar via Zoom, Renato Polimanti, 10/04 @ 4pm-5pm, " Big Data Analytics Applied to the Molecular Basis of Human Traits and Diseases"
elizavette.torres at yale.edu
elizavette.torres at yale.edu
Fri Oct 1 08:14:58 EDT 2021
<https://statistics.yale.edu/> Department of Statistics and Data Science
You are invited to a scheduled Zoom Seminar
RENATO POLIMANTI, Yale University School of Medicine
Monday, October 04, 2021
4:00PM to 5:00PM
Zoom:
https://yale.zoom.us/j/99169700816?pwd=SWEvWHI5d3dPNVdHMkZMZURMWWJPUT09
Password: 24
Title: Big Data Analytics Applied to the Molecular Basis of Human Traits and
Diseases
Information and Abstract:
Most human traits and diseases are characterized by a complex molecular
architecture where a wide range of biological pathways contribute to their
predisposition. Hypothesis-generating studies based on genomic screening (e.
g., genome-wide association studies, epigenome-wide association studies,
whole-genome sequencing, RNA sequencing, and bisulfite genomic sequencing)
are a powerful approach to dissect the polygenicity of the human phenome.
However, to be informative, these approaches require large cohorts
achievable with the integration of international consortia and large
biobanks to pool together samples and reach an adequate statistical power.
Beyond the identification of specific genes associated with traits and
diseases, large-scale genomic datasets can be used to investigate the
biology of the human phenotypic spectrum, modeling causal networks and
molecular mechanisms shared among physiological and pathological conditions.
Due to the growing number of large-scale genomic datasets available, there
is a rapid increase of methods to conduct computational investigations. The
goal of this seminar is to provide an overview of how we can use Big Data
Analytics to dissect the molecular basis of human traits and diseases. I
will present few examples of the studies conducted by my group, also
including collaborations with the Psychiatric Genomics Consortium, the
Million Veteran Program, and the COVID-19 Host Genetics Initiative, I will
describe current challenges and limitations and discuss the need to develop
new analytic approaches to improve our ability to translate molecular
findings into clinical practice.
Zoom is Yale’s audio and visual conferencing platform.
Topic: Yale S&DS Department Seminar
Time: 4:00pm - 5:00pm
Join from PC, Mac, Linux, iOS or Android:
<https://yale.zoom.us/j/99169700816?pwd=SWEvWHI5d3dPNVdHMkZMZURMWWJPUT09>
https://yale.zoom.us/j/99169700816?pwd=SWEvWHI5d3dPNVdHMkZMZURMWWJPUT09
Password: 24
Or Telephone:203-432-9666 (2-ZOOM if on-campus) or 646 568 7788
Meeting ID: 991 6970 0816
International numbers available: <https://yale.zoom.us/u/acBOaD1ic6>
https://yale.zoom.us/u/acBOaD1ic6
For H.323 and SIP information for video conferencing units please click
here:
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