[WTI-trainee] FW: REMINDER: Upcoming Bioimaging Sciences Seminar: Thursday, March 28th, 10am

[Guerrero-Medina, Giovanna]

See below.

Best,

Giovanna Guerrero-Medina, PhD
She/Her/Ella
Director for Diversity Equity & Inclusion,
Wu Tsai Institute at Yale
giovanna.guerrero-medina at yale.edu<mailto:giovanna.guerrero-medina at yale.edu>
203.785.2915 (office), 616.643.7666 (cell)
wti.yale.edu<https://wti.yale.edu/>


From: Mrrc_seminars <mrrc_seminars-bounces at mailman.yale.edu> on behalf of KRAMP, DANIELLE <danielle.kramp at yale.edu>
Date: Monday, March 25, 2024 at 8:45 AM
To: KRAMP, DANIELLE <danielle.kramp at yale.edu>
Cc: Lake, Evelyn <evelyn.lake at yale.edu>
Subject: Mrrc_seminars REMINDER: Upcoming Bioimaging Sciences Seminar: Thursday, March 28th, 10am
BIOIMAGING SCIENCES SEMINAR CO-SPONSORED BY MRRC NEUROSCIENCE
Thursday, March 28th, 2024 (10am)
TAC Second Floor (300 Cedar Street)

Alessandro Gozzi, Ph.D. The Italian Institute of Technology, in Rovereto, Italy


“Mechanisms of fMRI (dys)connectivity”


Biography-Alessandro Gozzi, PhD, is a senior scientist and director of the functional neuroimaging laboratory at the Italian Institute of Technology, in Rovereto, Italy. The Gozzi lab focuses on the study of the functional organization of the mammalian brain at the macroscale. A major goal of Gozzi’s research is to unravel the neural basis and dynamic organization of large-scale functional connectivity as measured with fMRI, and the underpinnings of its disruption in developmental disorders like autism. The Gozzi lab addresses these questions via the combination of cutting-edge functional MRI mapping with genetic and neural manipulations in the living mouse brain. This approach has laid the foundations for a new field of research in which large-scale neuroimaging readouts are used as probe of network activity and dysfunction across species.



Abstract-Brain disorders are often associated with disrupted or atypical functional connectivity. However, our ability to decode these signals into interpretable biological or physiological mechanisms remains limited.

To fill this knowledge gap, my lab has pioneered methods to map and manipulate intrinsic fMRI connectivity in the mouse brain. In my talk I will illustrate recent examples of the use of this platform to probe the underpinnings of intrinsic fMRI connectivity, and its disruption in brain disorders. Specifically, I will show how cross-species fMRI can help parse fMRI signatures of brain dysfunction into biologically dissociable neurosubtypes. I will then show how these subtypes can be linked to basic physiological mechanisms via the use of chemogenetic manipulations in rodents. These findings contribute to our understanding of the general principles governing fMRI connectivity in the mammalian brain. Importantly, they also support a simple framework whereby fMRI hyper- and hypo-connectivity observed in brain disease counterintuitively reflects reduced and increased interareal activity, respectively. Future extensions of this framework may offer opportunities to physiologically-decode fMRI dysconnectivity in human brain disorders.


Danielle Kramp
Senior Administrative Assistant
Yale University, Yale School of Medicine
Radiology and Biomedical Imaging PET Center
15 York Street|New Haven, CT 06510
P: (203) 785-3913| C: (859) 630-8880
E: danielle.kramp at yale.edu

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