[WTI-trainee] Leica Stellaris and Viventis microscopes available at NeuroLux

[Shao, Lin]

Dear All,



We are pleased to announce that the two newly acquired instruments at NeuroLux—described below—are now available for all WTI-affiliated researchers. Stacy Wilson, Director of the Neuroscience Imaging Core, will serve as the main contact for training, day-to-day support, and troubleshooting related to these instruments, and I will serve as her backup. Instrument reservations will be managed through FOM (fom.yale.edu).



To request training and obtain booking privileges, please contact either Stacy Wilson (stacy.wilson at yale.edu<mailto:stacy.wilson at yale.edu>) if you are an existing user of Neuroscience Imaging Core AND are affiliated with WTI, or Lin Shao (wti.microscopy at yale.edu<mailto:wti.microscopy at yale.edu> or lin.shao at yale.edu<mailto:lin.shao at yale.edu>) if otherwise or uncertain.





Details of the new microscopes



Leica Stellaris laser-scanning confocal with expanded functionality

  *   Besides fluorescence, this microscope is capable of two additional optical contrasting mechanisms:
     *
Fluorescence Lifetime Imaging Microscopy (FLIM) that allows contrasting fluorophores based on their difference in fluorescence lifetime and not on spectral separation; see Leica’s FALCON<https://www.leica-microsystems.com/products/confocal-microscopes/p/stellaris-8-falcon/> page for more details
     *
Coherent Raman Scattering<https://www.leica-microsystems.com/products/confocal-microscopes/p/stellaris-8-crs/> <https://www.leica-microsystems.com/products/confocal-microscopes/p/stellaris-8-crs/> (CRS) microscopy*, a label‑free imaging technique that uses vibrational contrast from molecules to generate high‑speed, chemically specific images of biological samples.

  *   Other features worth highlighting:
     *   White Light Lasers<https://www.leica-microsystems.com/science-lab/life-science/stellaris-white-light-lasers/> (between 440 nm and 790 nm) and HyD R detectors that allow imaging near-IR fluorophores
     *   Two-photon excitation and second-harmonic generation (SHG) microscopy*, both modalities enabled by the CRS module.


Features marked with an asterisk will be delivered in late spring.



Leica Viventis Deep<https://www.leica-microsystems.com/products/p/viventis-deep/> light-sheet microscope

  *   Ideal for imaging long-term development of small organisms, embryos, larvae, and organoids.
  *   Featuring user- and biology-friendly sample mounting in V-shaped wells filled with liquid or gel
  *   Up to 4 separate sample wells, each with different medium if needed, per imaging session
  *
Two sets of dual detection objectives (16x and 25x) to allow prioritizing resolution or field of view


Thank you and we look forward to seeing you at NeuroLux, located at SHM B-156, right next to the Neuroscience Imaging Core.



Best regards,



Lin



Lin Shao, Ph.D.

Director of Microscopy

100 College St, Room 1060

Wu Tsai Institute, Yale University


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